pharmacogenetics, the promise of translating personalized medicine into clinical pediatrics
نویسندگان
چکیده
منابع مشابه
Translating pharmacogenetics and pharmacogenomics into drug development for clinical pediatrics and beyond.
Pharmacogenetic and pharmacogenomic investigations conducted in children must consider that human development from conception through to adolescence is a rapidly changing, dynamic process. An improved understanding of the gene networks that are involved in growth and development and of the unintended consequences of modulating those systems could provide insights into the susceptibility of an i...
متن کاملPharmacogenetics/genomics and personalized medicine.
Despite the marked advances in drug therapy, some patients do not respond favorably or suffer severe adverse drug effects. Pharmacogenetic studies have shown that polymorphisms of drug metabolizing enzymes, transporters and receptors contribute to variable drug response. Owing to the complexity of drug actions, a broader genomics approach aims at finding new drug targets and optimizing therapy ...
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More than 30 years of genetic research on the CYP2C19 gene alone has identified approximately 2,000 reference single nucleotide polymorphisms (rsSNPs) containing 28 registered alleles in the P450 Allele Nomenclature Committee and the number continues to increase. However, knowledge of CYP2C19 SNPs remains limited with respect to biological functions. Functional information on the variant is ess...
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pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...
متن کاملPharmacogenetics, Personalized Medicine, and Race
Metabolic pathways — the chains of chemical reactions that occur in each cell in the body — are affected by a wide range of DNA mutations, including single nucleotide polymorphisms (SNPs); gene deletions, duplications, and insertions; mutations in the regulatory elements of genes; and variations in gene copy number. The identification of gene variants (alleles) that influence drug metabolism is...
متن کاملPharmacogenomics : The Promise of Personalized Medicine
Pharmacogenetics and pharmacogenomics deal with the genetic basis underlying variable drug response in individual patients. The traditional pharmacogenetic approach relies on studying sequence variations in candidate genes suspected of affecting drug response. On the other hand, pharmacogenomic studies encompass the sum of all genes, i.e., the genome. Numerous genes may play a role in drug resp...
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عنوان ژورنال:
journal of comprehensive pediatricsجلد ۷، شماره ۲، صفحات ۰-۰
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